MPV 1248 hydrochloride
1H-Imidazole, 4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-, monohydrochloride
CAS: 104075-48-1
Molecular Formula: C14H16N2.HCl
MPV 1248 hydrochloride - Names and Identifiers
| Name | 1H-Imidazole, 4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-, monohydrochloride |
| Synonyms | Antisedan Atipamezole HCL MPV1248 hydrochloride MPV 1248 hydrochloride Atipamezole hydrochloride 4-(2-Ethyl-2-indanyl)imidazole hydrochloride 4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole hydrochloride 1H-Imidazole, 4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-, monohydrochloride |
| CAS | 104075-48-1 |
| EINECS | 105-700-9 |
| InChI | InChI=1/C14H16N2.ClH/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14;/h3-6,9-10H,2,7-8H2,1H3,(H,15,16);1H |
MPV 1248 hydrochloride - Physico-chemical Properties
| Molecular Formula | C14H16N2.HCl |
| Molar Mass | 248.75 |
| Melting Point | 211-215° |
| Boling Point | 396°C at 760 mmHg |
| Flash Point | 193.3°C |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 1.17E-06mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| Merck | 14,861 |
| Storage Condition | Sealed in dry,Room Temperature |
| In vitro study | The affinity of atipamezole for α 2 -adrenoceptors and its α 2 /α 1 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α 2 -adrenoceptors. It has negligible affinity for 5-HT 1 , 5-HT2 and I2 bindings sites. |
| In vivo study | Atipamezole is well tolerated in rodents. In anesthetized, normotensive rats, the cardiovascular effects of atipamezole (0.01–1 mg/kg, i.v.) are rather modest. Atipamezole is commonly used by veterinarians to awaken animals from sedation or anesthesia. Atipamezole increases sexual activity in rats and monkeys. In animals with sustained nociception, atipamezole increases pain-related responses by blocking the noradrenergic feedback inhibition of pain. Atipamezole at low doses has beneficial effects on alertness, selective attention, planning, learning, and recall in experimental animals, but not necessarily on short-term working memory. |
MPV 1248 hydrochloride - Risk and Safety
| RTECS | NI6139000 |
| Toxicity | LD50 in male, female rats (mg/kg): >50, 44 s.c. (Scheinin) |
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